"This fusion created an entirely new protein that took on a central role in the auxin signaling pathway," says Dolf Weijers, Professor of Biochemistry. The chromatin factor enables ARF proteins to ...

In the p53 pathway, signals such as DNA damage induce the ARF (also known as p14 in humans and p19 in mice) product of the CDKN2A locus. ARF increases p53 levels by sequestering MDM2, which ...