Transcription factors can also evolve by the acquisition or loss of one of its other functional domains. For example, the loss of a transcriptional activation domain could turn an activator into a ...

Transcription factors activate genes through the phase separation capacity of their activation domains. Cell 2018, 175: 1842-1855. Taatjes, DJ. Transcription factor–Mediator interfaces: multiple and ...

One distinct feature of transcription factors is that they have DNA-binding domains that give them the ability to bind to specific sequences of DNA called enhancer or promoter sequences.

A multi-institutional team of investigators have developed a catalog of transcription factor binding sites that regulate gene ...

To change this, specialized transcription factors, called pioneer transcription factors, can access the DNA and activate it ... revealed that the DNA-binding domain of Nr5a2 competes with a ...

A research team at KAIST has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation ...