Genomic Interrogation of Secondary-Type Acute Myeloid Leukemia: Response and Outcomes to Contemporary Therapies,” published in the February 2025 issue of American Journal of Hematology by Senapati et ...

such as ALL (acute lymphocytic leukemia), AML (acute myeloid leukemia), and CML (chronic myeloid leukemia). CLL is the most common leukemia in adults. Most people get diagnosed in their 60s and 70s.

However, we found that most acute myeloid leukemia (AML) cells, especially M4 and M5 subtypes, produce TNF and show basal level activation of RIP1/RIP3/MLKL signaling, yet do not undergo necroptosis.