However, despite this intense global interest, finding enzyme-activating compounds has been a challenge because they typically rely on a mechanism called allosteric modulation, a process that is ...

Controlling protein function rather than protein production has several advantages, including a potentially quicker response to stimuli and the ability to study an enzyme's catalytic function ...

those given placebo. Treatment with an oral allosteric modulator was nonsuperior to placebo at 6 weeks in adults with Parkinson’s disease whose symptoms included fall risk and cognitive issues ...

Gain’s lead program in Parkinson’s disease has been awarded funding support from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and The Silverstein Foundation for Parkinson’s with GBA, ...

Pfizer (NYSE:PFE) has entered into a collaborative research agreement with Atavistik Bio for the discovery of novel precision allosteric therapeutics. The collaboration will utilize Atavistik's ...

Allosteric effectors that are not competitive can serve as effective activators of weak enzymes or as inhibitors of overactive enzymes. Allosteric activators or inhibitors induce small ...

Gain Therapeutics, Inc. (Nasdaq: GANX) (“Gain”, or the “Company”), a clinical-stage biotechnology company leading the discovery and development of the next generation of allosteric small molecule ...

Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...

Enzymes can be regulated by various means, such as allosteric regulation (binding of effector molecules), covalent modification (e.g., phosphorylation), and changes in pH or temperature. The Michaelis ...