Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative ...

The term 'autophagy' was chosen to distinguish the lysosomal degradation ... to analyse mammalian cells that express autophagy proteins tagged with fluorescent markers. Time-lapse studies provide ...

which are linked to imbalances in lipid and protein production and degradation. Furthermore, improving autophagy function has the potential to slow cellular ageing by preserving organelle quality ...

demonstrating the proficiency of MZ1 to position the target protein for degradation and the favorability of the target protein for ubiquitination by UBE2R1. The importance of degraders for ...

And it also degrades and recycles proteins when cells become starved. As a result, it plays a role in maintaining the constant environment in the living body. *2 selective autophagy Traditionally, ...

Metastatic progression is driven by the expression and stabilization of pro-metastatic proteins. This study reveals how ...

Intracellular constituents such as proteins and organelles are turned over by unremitting synthesis and degradation. This dynamic turnover is critical for homeostasis, development, and environmental ...

which are linked to imbalances in lipid and protein production and degradation. Furthermore, improving autophagy function has the potential to slow cellular aging by preserving organelle quality ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently ... ubiquitylation, protein translation, degradation, and trafficking ...

TFE3 overexpression attenuates α-Syn toxicity in a mouse model of Parkinson's disease. TFE3 overexpression rescues autophagy defects of dop ...