It is from these cells, which express a gene called Krt5 that helps to build the structure of cells, that lung squamous cell carcinoma (LUSC) eventually develops.

Lung cancer remains the world’s deadliest cancer, and cigarette smoke is its chief culprit. Chemicals in tobacco, such as polycyclic aromatic hydrocarbons (PAHs), damage DNA and trigger the mutations ...

These cells, which are a type of basal cell in the windpipe, outcompete other cells and invade the lung. The findings, which could lead to earlier detection methods, have been reported in Science.

Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells. Cell Stem Cell , 2023; DOI: 10.1016/j.stem.2023.07.014 ...

Image of a lung lobe from a carcinogen-exposed mouse. Cells expressing the basal cell marker KRT5 have been fluorescently labelled and can be seen spreading throughout the bronchial tree Credit ...

A new study found that deleting a gene called KMT2D caused normal (basal) lung cells grown in complex cultures called organoids to transform into lung squamous carcinoma (LUSC) cells.

Basaloid: These cancer cells resemble the basal cells found in the deepest layers of the lung epithelium, and tend to be arranged in lobules. Signs and Symptoms of Squamous Cell Lung Cancer ...

basal cells; News tagged with basal cells. Date. 6 hours 12 hours 1 day 3 days all. Rank. ... New target for improving recovery from lung injury identified. After a severe bout with a respiratory ...

Learn more about advanced basal cell carcinoma, such as where it forms, how it’s different from other skin cancers, what makes it advanced, and more.

More information: Yuanwang Pan et al, KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition, Cancer Cell (2022). DOI: 10.1016/j.ccell.2022.11.015 Journal ...