The nascent pri-microRNA (pri-miRNA) transcripts are first processed into approximately 70-nucleotide pre-miRNAs by Drosha inside the nucleus. Pre-miRNAs are transported to the cytoplasm by ...
The biogenesis of miRNAs involves a multi-step process that begins ... where they are further cleaved by the Dicer enzyme to generate mature miRNA duplexes. One strand of the mature miRNA duplex, ...
In addition, exosome delivery systems struggle with preserving bioactivity and maintaining adaptable miRNA cargoes throughout ... for efficient biogenesis of exosomes. Through the synergistic ...
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