The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

Other targets for entry inhibitors include two co-receptors on the cell surface—CCR5 and CXCR4—which together with CD4 mediate virus binding and membrane fusion 3. As CCR5, but not CXCR4 ...

5B). MIP-1α specifically bound to CCR5-expressing cells and not to control cells expressing another chemokine receptor, CXCR4. The binding of radiolabeled MIP-1α to the CCR5-expressing cells was ...

The discovery of HIV coreceptors, such as CCR5 and CXCR4, has prompted a search for inhibitors against these receptors as an alternative therapy to HAART. Although new anti-HIV drugs that target ...