Cytochrome P450 enzymes (CYPs) are a large family of enzymes that play a crucial role in the metabolism of various substances, including drugs and xenobiotics (foreign compounds). In cancer ...

Microbial factories provide a sustainable alternative to tree sap for producing elusive plant molecules, offering new ...

Aim: The present study aimed to investigate the human genetic diversity of the CYP450 superfamily in order to identify functional interethnic differences and analyze the role of CYP450 enzymes in ...

Grapefruit juice, a health food staple, can interact with statins, rheumatoid arthritis drugs and psoriasis treatments.

These compounds are broken down by an enzyme in the intestines called cytochrome P450 3A4 (CYP3A4). The resulting products will then bind to the enzyme, which prevents it from breaking down the ...

The drug is cleared by cytochrome P450 (CYP)3A4 metabolism. Peak plasma concentrations are achieved about 1.5 hours after oral administration. Its absorption is not affected by food. Eplerenone ...

PUFA metabolites controlled by cytochrome P450 (CYP) impact foetal development, leading to deficits strongly associated with symptoms of ASD. However, further research is required to understand ...

A growing body of evidence links use of proton pump inhibitors to kidney problems, including kidney failure in patients with existing CKD.