Opioid analgesic risk evaluation and mitigation strategy (REMS); Cytochrome P450 3A4 interaction. Assess the potential need for access to naloxone when initiating and renewing therapy. Consider ...

Concomitant use or discontinuation of CYP3A4 inhibitors or inducers ... use with benzodiazepines or other CNS depressants; Cytochrome P450 3A4 interaction. Abuse potential (monitor).

5-hydroxyomeprazole is then transformed into 5-hydroxyomeprazole sulfone by CYP3A4. Omeprazole is metabolized ... could be a more practical. The CYP isoenzymes participating in the metabolism ...