Prof. MENG Guangxun's team from the Shanghai Institute of Immunity and Infection of the Chinese Academy of Sciences, and collaborators, have revealed a novel mechanism whereby a short form of IL-18, ...
We established that Lyn is cleaved in imatinib-treated parental K562 cells in a caspase-dependent manner ... activity and likely on the BCR–ABL pathway. In this study, the role of the caspase ...
Intriguingly, short IL-18 promotes NK cell anti-tumor activity by modulating key signaling pathways ... Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth ...