Where and when do cyclins act on the cell cycle? (A) Cycling cells undergo three major transitions during their cell cycle. The beginning of S phase is marked by the onset of DNA replication ...

are the primary concerns of cell cycle biologists. The most significant progress in this research field came with the demonstration that specific protein complexes involving cyclins were critical ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz investigated ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz investigated ...

Arnold, R.A. Weinburg, "Physical interaction of the retinoblastoma protein with human D cyclins," Cell, 73:499-511 ... Both types of proteins are important in regulating the cell cycle, the many-step ...

Scientists have identified a new variant of the cell cycle that could provide insight into how diseases like cancer occur. Maggie Chen is a scientist and science journalist covering health, biology, ...

Cell division is essential for the survival of all living organisms, from the simplest yeast to complex human beings.

Cyclins regulate steroid receptor action in cyclin-dependent kinase (CDK)-dependent and independent manners. In addition to regulating the cell cycle, cyclin A2 (CCNA2) also mediates female sex ...

Cyclins and cyclin-dependent kinases (CDKs) regulate the activity of E2F and Rb to drive cell cycle progression. Disrupting this interaction has shown lethality in cancer cells harboring alterations ...

Existing methods of targeting cyclin-dependent kinases, which are crucial for cell cycle progression ... macrocycle therapies ...