Based on meta-analysis of over 100 studies of transmembrane cell-surface receptors, experts have proposed a new model for receptor activation -- the "rotation model." If the model proves correct ...

However, a greater quantity of GluR1 in the cell did not increase the quantities of receptors on the cell membrane or in synapses. Yet this was the case for GluR2.

Taste, pain, or response to stress—nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers at the University ...

Special molecules called T cell receptors (TCRs) sit on the cell membrane, where they receive messages from other cells. You can imagine TCRs as fire-spotters, the lookouts who scan for smoke from ...

Nature Medicine - Cell membrane estrogen receptors resurface. Collins, P. & Webb, C. Estrogen hits the surface. Nature Med. 5, 1130–1131 (1999). Article CAS Google Scholar ...

Drug discovery can be a long and complex process. Medicines for neurodegenerative diseases like Alzheimer's disease are among ...

Engineered cell therapies rely on synthetic receptors to transduce external signals into intracellular responses. The precise ...

Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. M. Razandi, A. Pedram, G.L. Greene, E.R.

In the example of CAR T-cell therapies, structurally tuning receptors can avoid tonic signaling, or activation in the absence of the target stimulus, ... membrane localization, protein stability.

This valuable manuscript investigates the localisation of nutrient receptors in bloodstream stage trypanosomes, with implications for both nutrient uptake and immune evasion. Results after direct ...