Nature Structural & Molecular Biology - The extended and eccentric E-DNA structure induced by cytosine methylation or bromination Skip to main content Thank you for visiting nature.com.

DNA methylation refers to the addition of a methyl (CH3) group to the DNA strand itself, often to the fifth carbon atom of a cytosine ring. This conversion of cytosine bases to 5-methylcytosine is ...

This methylation can inhibit gene expression via two mechanisms; modifying the cytosine base to inhibit DNA binding factors or activating 5mC binding proteins [2]. These proteins recruit factors that ...

There is tremendous ferment in the field of epigenetics as the relationships between chromatin structure and DNA methylation patterns become clearer. Central to this activity is the realization ...

Cytosine was first discovered in 1894 by Albrecht Kossel, a German biochemist. Kossel isolated cytosine from calf thymus tissues and found that it was a component of nucleic acids. This discovery, ...

A research team led by a biochemist at the University of California, Riverside has solved the crystal structure for an enzyme that plays a key role in DNA methylation, the process by which methyl ...

“It especially has important implications in cancer therapy in the long term,” he said. Study results appear today in Nature. The DNMT3A structure that Song’s team cracked explains why mammalian DNA ...

DNA methylation involves the addition of a methyl group (-CH 3) to cytosine residues within DNA. Typically, only cytosine residues adjacent to guanine are methylated, and such pairs are identified as ...

Bisulfite Conversion of Methylated Cytosine. Cytosine methylation occurs when a methyl group binds to the fifth carbon of a cytosine to form 5-methylcytosine (5mC). Researchers cannot detect 5mC with ...

More information: Extensive N4 Cytosine Methylation is Essential for Marchantia Sperm Function, Cell (2025). ... the structure carrying the male sexual organs of the liverwort Marchantia polymorpha.