Nature Structural & Molecular Biology - The extended and eccentric E-DNA structure induced by cytosine methylation or bromination Skip to main content Thank you for visiting nature.com.

DNA methylation refers to the addition of a methyl (CH3) group to the DNA strand itself, often to the fifth carbon atom of a cytosine ring. This conversion of cytosine bases to 5-methylcytosine is ...

This methylation can inhibit gene expression via two mechanisms; modifying the cytosine base to inhibit DNA binding factors or activating 5mC binding proteins [2]. These proteins recruit factors that ...

Cytosine was first discovered in 1894 by Albrecht Kossel, a German biochemist. Kossel isolated cytosine from calf thymus tissues and found that it was a component of nucleic acids. This discovery, ...

Bisulfite Conversion of Methylated Cytosine. Cytosine methylation occurs when a methyl group binds to the fifth carbon of a cytosine to form 5-methylcytosine (5mC). Researchers cannot detect 5mC with ...

“It especially has important implications in cancer therapy in the long term,” he said. Study results appear today in Nature. The DNMT3A structure that Song’s team cracked explains why mammalian DNA ...

Your DNA consists of four bases, called cytosine, guanine, adenine, and thymine. A chemical unit called a methyl group, which contains one carbon and three hydrogen atoms, can be added to cytosine.

Thymine (T) is one of the four nucleobases found in DNA, alongside adenine (A), guanine (G), and cytosine (C). It is a pyrimidine derivative, meaning it has a single-ring structure. Thymine plays a ...

DNA methylation is an epigenetic modification that alters gene expression, where aberrant methylation patterns contribute to the pathogenesis of numerous diseases. However, most next generation short ...

More information: Extensive N4 Cytosine Methylation is Essential for Marchantia Sperm Function, Cell (2025). ... the structure carrying the male sexual organs of the liverwort Marchantia polymorpha.