O ur DNA undergoes constant damage and repair. The most severe damage happens when the DNA breaks into two pieces, known as a ...

"A key mechanism we identified is that RNA can help position and hold the broken DNA ends in place, facilitating the repair process," explained Storici, whose team conducted the research in both ...

QUICK FIX: From left, Frederick Alt and Guillermo Taccioli and their colleagues identified DNA-dependent kinase as a key enzyme involved in DNA repair. The way that DNA repairs itself recently has ...

DNA ligase IV is a 911-amino acid polypeptide that plays a role in the repair of double-strand DNA breaks via non-homologous end joining (NHEJ). Yeast cells contain 2 separately encoded DNA ligases, ...

In a groundbreaking shift in our understanding of mutations, researchers have discovered types of DNA damage in healthy cells ...

DNA damage and repair refers to the creation and correction ... report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

18 DSB repair pathways can be divided into two basic subgroups ... A heterodimeric complex of the Ku70 and Ku80 proteins binds the ends recruiting DNA protein kinase. This stabilises the ends and ...

This is why mutations in DNA repair genes often underlie earlier-onset cancers ... a component of the MRN complex, leading to efficient DNA end resection at break points. This study demonstrates the ...

and non-homologous end-joining (NHEJ). Some enzymes may participate in more than one of these repair systems. DNA damage also triggers biochemical signals activating checkpoints responsible for delay ...