What are Promoters and Enhancers? The genome contains a large number of non-coding DNA regulatory elements, including silencers, insulators, promoters and enhancers, which play an important role in ...

Wei Li, Qianben Wang and colleagues analyze genome-wide epigenetic patterns in tumor and normal tissues and find that broad H3K4me3 peaks are associated with increased transcription elongation and ...

In a somewhat imperfect analogy, if the core promoter were the ignition switch of a car engine, enhancers would act as the accelerator, and silencers as the brakes. Eukaryotic genes can include ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted upon by an enzyme called RNA polymerase. This is a molecular machine which ...

Role for enhancers in bursts of gene activity Date: July 19, 2016 Source: Princeton University Summary: A new study suggests that sporadic bursts of gene activity may be important features of ...

Using anew method called Net-CAGE, researchers identified as many as 20,000 new enhancers in humans. They found that while promoters are activated in a variety of cell types, enhancers tend to ...

In some cases, enhancer-promoter interactions only happened when the gene was expressed, so the physical proximity between the two directly affected gene expression. This is known as an ...

A team led by University of Pittsburgh School of Public Health geneticists has shown, for the first time, that a gene “silencer” that resides in junk DNA is directly sparing people from a ...

As an example, the researchers focused on a gene called Nanog, a 770,000-base length of DNA on chromosome 6, which has a promoter and three enhancer regions and is known to undergo transcriptional ...

A team led by University of Pittsburgh School of Public Health geneticists has shown, for the first time, that a gene "silencer" that resides in junk DNA is directly sparing people from a ...