The genome contains a large number of non-coding DNA regulatory elements, including silencers, insulators, promoters and enhancers, which play an important role in gene expression.

Broad H3K4me3 is associated with increased transcription elongation and enhancer activity, which together lead to exceptionally high gene expression, and is distinct from other broad epigenetic ...

Strikingly, enhancer regions can be thousands of DNA base pairs away from the genes they control. The 3D looping of DNA brings enhancers and the promoters of their target genes into contact.

The researchers found that snippets of DNA called enhancers can boost the frequency of bursts, suggesting that these bursts play a role in gene control.

A team led by University of Pittsburgh School of Public Health geneticists has shown, for the first time, that a gene “silencer” that resides in junk DNA is directly sparing people ...

Researchers have revealed a new mechanism underlying how spatial distance between specific regions of DNA is linked to bursts of gene activity. Using advanced cell imaging techniques and computer ...

People with ADLD have a duplication of the lamin B1 gene without the silencer—and that results in demyelination and disease symptoms.

Eukaryotic genes can include several enhancers and silencers, and two genes may contain some identical enhancer or silencer elements, but no two genes are precisely alike in the combination of ...

In some cases, enhancer-promoter interactions only happened when the gene was expressed, so the physical proximity between the two directly affected gene expression.

As an example, the researchers focused on a gene called Nanog, a 770,000-base length of DNA on chromosome 6, which has a promoter and three enhancer regions and is known to undergo transcriptional ...