In some cases, enhancer-promoter interactions only happened when the gene was expressed, so the physical proximity between the two directly affected gene expression. This is known as an ...

Using a new technique, researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible.

Enhancers are segments of DNA that activate gene expression by interacting with the gene’s promoter. Enhancers and promoters form physical contact, which imparts the message to the cell of when to ...

Using anew method called Net-CAGE, researchers identified as many as 20,000 new enhancers in humans. They found that while promoters are activated in a variety of cell types, enhancers tend to ...

A team led by University of Pittsburgh School of Public Health geneticists has shown, for the first time, that a gene “silencer” that resides in junk DNA is directly sparing people from a ...

As an example, the researchers focused on a gene called Nanog, a 770,000-base length of DNA on chromosome 6, which has a promoter and three enhancer regions and is known to undergo transcriptional ...

The study revealed several key insights. Across the three cell types, approximately 41.7% of the analyzed CREs exhibited activity. Promoters, which start gene transcription, showed a dependence on ...

DNA enhancers, crucial for gene regulation, can be distant from the genes they control, requiring 3D looping to interact with promoters. A shared genetic mechanism appears to regulate both ...