Cure Today10d
Breaking Down the FDA Labeling Update of Xeloda and 5-FU in Cancer Care
The FDA has updated the product labeling for Xeloda and 5-FU to highlight the risks associated with dihydropyrimidine ...
Cure Today9d
An Expert Breaks Down What DPD Is and Labeling Updates From The FDA
Dr. Gabriel A. Brooks discusses the recent FDA product labeling update for Xeloda and 5-FU which aims to highlight risks ...
Medscape1mon
Dihydropyrimidine Dehydrogenase Gene as a Major Predictor of Severe 5-fluorouracil Toxicity
Whereas many of the earlier studies on DPYD variation and 5-FU toxicity were focused on selected ... of 44 additional base pairs in the mature DPD mRNA, causing a shift in the reading frame ...
Hosted on MSN1mon
Opinion: A route to safer chemotherapy
This enzyme, also known as DPD, is usually caused by inherited changes in a particular gene. Currently, there are internationally accepted dosing guidelines for 5-FU, adjusted according to DPD ...
Medscape1mon
Capecitabine: Have We Got the Dose Right?
Following conversion to 5-FU, 60–90% of capecitabine is catabolized by dihydropyrimidine dehydrogenase (DPD) ultimately to FBAL and 10–20% is excreted in urine unchanged. It has also been ...