Recent years have seen an upsurge of brain imaging, with renewed interest in techniques like electron microscopy, ... uses jets of liquid nitrogen to "snap-freeze" brain tissue down to -90oC, ...

High-pressure freezing can be combined with optogenetics (‘flash-and-freeze’) or electrical field stimulation (‘zap-and-freeze’) to close this gap. In these methods, neurons are stimulated then frozen ...

The freeze-fracture technique consists of physically breaking apart (fracturing) a frozen biological sample; structural detail exposed by the fracture plane is then visualized by vacuum-deposition ...

Imagine owning a camera so powerful it can take freeze-frame photographs of a moving electron—an object traveling so fast it could circle the Earth many times in a matter of a second.

An alternative method, called cryo-electron tomography (cryo-ET), provides clearer images of the brain's smallest parts in a more native state, however, it requires freezing.

Freeze-frame: World's fastest microscope that can see electrons in motion Date: August 21, 2024 Source: University of Arizona Summary: A team of researchers has developed the first transmission ...

This study demonstrates a new approach to examining these types of electrical switching processes. This ultrafast electron microscopy method allows researchers to observe how microelectronic ...

FREEZE-FIXATION implies rapid freezing of small specimens followed by vapour fixation ... NILSSON, O. Freeze-fixation, a New Method for Electron Microscopy. Nature 208, 90 (1965). https ...

Using technologies like electron microscopy (EM) it is possible to capture molecular mechanisms in great detail, but not when these mechanisms are currently moving. The field of cryomicroscopy ...

W ith the inventions of transmission electron microscopy (TEM) in 1931 and scanning electron microscopy (SEM) shortly after in 1937, scientists gained an unprecedented ultrastructural view of the ...

High-pressure freezing can be combined with optogenetics (‘flash-and-freeze’) or electrical field stimulation (‘zap-and-freeze’) to close this gap. In these methods, neurons are stimulated then frozen ...

"This transmission electron microscope is like a very powerful camera in the latest version of smartphones; it allows us to take pictures of things we were not able to see before – like electrons.