Ferroptosis begins with phospholipid peroxidation, leading to membrane damage rupture and cell death. ... Sensing stress within the endoplasmic reticulum (ER), ...

Boosting ferroptosis to defeat cancer cells. Having discovered the role of EMCSs in ferroptosis, the researchers found that disrupting the physical link between the endoplasmic reticulum and ...

Altered immunometabolism at the interface of increased endoplasmic reticulum (ER) stress in patients with type 2 diabetes. Journal of Leukocyte Biology , 2015; 98 (4): 615 DOI: 10.1189/jlb.3A1214-609R ...

Prolonged Stress Sparks Endoplasmic Reticulum To Release Calcium Stores And Induce Cell Death In Aging-related Diseases. ScienceDaily . Retrieved June 3, 2025 from www.sciencedaily.com / releases ...

Discovered over a decade ago, ferroptosis is a form of non-apoptotic cell death that depends on the production of reactive oxygen species (ROS), iron and lipid peroxidation. Ferroptosis has been a ...

All the latest science news on endoplasmic reticulum from Phys.org. Find the latest news, advancements, ... Adipocyte-hepatocyte signaling mechanism uncovered in endoplasmic reticulum stress response.

Mechanistically, CPI-613 induces endoplasmic reticulum (ER) stress and triggers the expression level of XBP1s, which transcriptionally suppresses the expression of THBS2 gene. In addition, THBS2 ...

Metabolic-associated fatty liver disease (MAFLD), which was previously known as non-alcoholic fatty liver disease (NAFLD), represents a major health concern worldwide with limited therapy.

Knockdown of iGPX4 by siRNA alleviated lipid stress, ferroptosis and cell injury. Mechanistically, the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic ...