More information: Sara Parsa et al, The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing, Nature Cancer (2020).DOI: 10.1038 ...

The metabolic enzyme IL4I1 ... An example of this are degradation products of the amino acid tryptophane, which we take in with our food as a building block of proteins.

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Scientists at the Sloan Kettering Institute have found that increased activity of a normal metabolic enzyme can lead to cancer. The enzyme, SHMT2, is a driver of a large portion of B cell ...

Glycolysis is a central metabolic pathway by which cells obtain energy from sugar. Cancer cells in particular have long been ...

To address childhood malnutrition—which affects 200 million children globally—researchers at Washington University School of Medicine in St. Louis have developed a therapeutic food that ...

Here, we investigate the possible role of the enzyme serine hydroxymethyltransferase-2 (SHMT2) in lymphoma initiation. SHMT2 localizes to the most frequent region of copy number gains at ...

Metabolic disorders are conditions that affect any aspect of metabolism. Examples of metabolic disorders include diabetes, Gaucher’s disease, and hemochromatosis. Symptoms can include tiredness ...

Columbia University scientists, in collaboration with researchers from Nimbus Therapeutics, have demystified a metabolic enzyme that could be the next major molecular target in cancer treatment. The ...

Researchers at WashU Medicine have discovered a gut bacterial enzyme with previously unknown metabolic capabilities. Shown are the structures of the bacterial version of the enzyme, called FAAH ...

Because of how aggressively they divide, cancer cells have an increased demand for building materials and energy. They meet these added demands by altering their metabolism — taking in larger amounts ...

Because of how aggressively they divide, cancer cells have an increased demand for building materials and energy. They meet these added demands by altering their metabolism — taking in larger amounts ...