To improve the efficacy of gene therapy when using anti-sickling beta globin gene transfer, they added cyclosporin (CsH) to increase transduction by inhibiting lentiviral restriction factors.

To improve the efficacy of gene therapy when using anti-sickling beta globin gene transfer, ... Many individuals with sickle cell anemia undergoing controlled ovarian hyperstimulation (COH ...

Some examples of genetic diseases linked to cytosine mutations include: Sickle cell anemia: A single C-to-T mutation in the beta-globin gene leads to the production of abnormal hemoglobin, causing red ...

Next, the investigators queried the identity of the pulled-down DNA by PCR, using primer pairs to amplify short sequences spanning the entire β-globin gene region. The DNA that was pulled down by ...