The conserved oligomeric Golgi (COG) complex is a pivotal regulator of vesicular trafficking and glycosylation in eukaryotic cells. By ensuring the accurate localisation of glycosyltransferases ...

Our cells carry out hundreds of thousands of important functions every day, all of which are carefully orchestrated at a microscopic scale. However, the precise mechanisms that influence the luminal ...

The Golgi body (or Golgi complex, apparatus), and Endoplasmic reticulum (ER) are both organelles found in the majority of eukaryotic cells. They are very closely associated and show both ...

Golgi glycosylation malfunction and dysregulation has also been implicated in the proliferation of cancer cells and disease progression. ... “When the COG protein complex doesn't work properly, ...

Study: Glycosylation and disulfide bonding of wild-type SARS-CoV-2 spike glycoprotein. ... on wild-type SARS-CoV-2 S glycoprotein trimer are modified in the Golgi-complex of the host cell.

Many proteins undergo an assembly line-style process of glycosylation as they travel from a cellular structure called the endoplasmic reticulum (ER) to the Golgi apparatus and on through its ...

The cover for issue 28 of Oncotarget features Figure 5, 'TMEM165 expression levels alters N-linked glycosylation,' by Murali, et al., and reported that the TMEM165 protein was not detected in non ...