Chinese researchers have developed a technology that sheds light on how the three-dimensional (3D) organization of plant genomes influences gene expression—especially in photosynthesis.

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

The size of Single Technologies’ 3D DNA sequencing matrix (left) compared to Illumina’s S4 flow cell (right). “If you take all the Post-it notes and put them on the table, you could fill a ...

To explore the 3D morphology of the existing chromosomes, Aiden modified an in situ Hi-C protocol, dubbed PaleoHi-C. 2 This technique, adapted for ancient samples and combined with DNA sequencing, ...

Chemists have found a new way to determine 3D genome structures, ... known as Hi-C, ... so a single DNA sequence can give rise to many different possible conformations.

3D genomics can provide a picture on the puzzle box. 3D sequencing techniques, such as Paleo Hi-C, help researchers piece together DNA by taking into account where the fragments are located in the ...

Using the genomes of modern elephants as a template, the researchers used Hi-C to create the first 3D map of the mammoth genome. This revealed that mammoths had 28 chromosomes, the same amount as ...

Hi-C “glues” together sections that are near one another and tags the pairs. Alongside modern DNA sequencing, the technique produces a catalog of DNA fragments that interact in physical space. Like a ...

Chinese researchers have developed a technology that sheds light on how the three-dimensional (3D) organization of plant genomes influences gene expression—especially in photosynthesis.

MIT chemists have now come up with a new way to determine those 3D genome structures, ... known as Hi-C, ... so a single DNA sequence can give rise to many different possible conformations.