Researchers at Icahn School of Medicine at Mount Sinai recently identified a particular histone post-translational modification that is linked to a greater susceptibility to different types of ...

This article examines the contributions of mass spectrometry-based proteomics in the identification and quantification of histone post-translational modifications.

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

Histone acetylation controls, almost exclusively, euchromatin protein dynamics; lamin A expression regulates heterochromatin protein dynamics, and G9a regulates both euchromatin and ...

Dr. Parthun and colleagues performed a quantitative proteomics analysis of newly replicated chromatin in cell lines from wild type and histone acetyltranferase 1 (Hat1) deletion-mutant mouse embryos.

They can also undergo a process called 'histone modification' where parts of the histone protein experience chemical and structural changes through the addition or removal of specific molecules.

Modification of histone tails, by acetylation, methylation or phosphorylation, affects the local chromatin structure and the transcriptional regulation of adjacent genes. Pericentric heterochromatin ...

Not only did TRIM24 "read" histone modifications, but the act of reading resulted in TRIM24 itself being modified with a small protein tag called SUMO.

Scientists have observed changes to the gene-regulating factors during zebrafish development and discovered that modifications to 'histone H3', one of the proteins around which DNA is bound, play ...

ChIP-Seq is a powerful tool that enables researchers to investigate and understand protein−DNA interactions and the influence these have on gene expression and cell function.

Histone H4 is arguably the easiest histone to work with, possessing the best ionization, separation and fragmentation properties of any histone at both the polypeptide and intact protein level.