Amidst the fast-growing science of epigenetics, Creative Proteomics, a leading provider of proteomics and bioinformatics services, has dramatically extended its workbench with the launch of an ...

This article examines the contributions of mass spectrometry-based proteomics in the identification and quantification of histone post-translational modifications. News & Perspective Drugs & Diseases ...

The balance between acetylation and deacetylation of histone proteins plays a critical role in the regulation of genomic functions. Aberrations in global levels of histone modifications are linked ...

The Antibody-based Proteomics Core provides cutting edge antibody-based proteomic platforms for both validation and protein biomarker discovery, ... We have developed an epigenetic RPPA platform to ...

Creative Proteomics, a leading provider of advanced proteomics services globally, has recently extended its services portfolio with protein post-translational modification (PTM) analysis.This new ...

Dr. Parthun and colleagues performed a quantitative proteomics analysis of newly replicated chromatin in cell lines from wild type and histone acetyltranferase 1 (Hat1) deletion-mutant mouse embryos.

Having grown beyond early ‘proof-of-principle’ studies, top-down proteomics is now extensively used to analyze intact proteins in numerous applications. Here, we discuss how the top-down proteomics ...

Modification of histone tails, by acetylation, methylation or phosphorylation, affects the local chromatin structure and the transcriptional regulation of adjacent genes.Pericentric heterochromatin ...

Emory University study shows some of the first direct evidence of a process required for epigenetic reprogramming between generations – a finding that could shed more light on the mechanisms of ...

Scientists at Tokyo Institute of Technology (Tokyo Tech) observed changes to the gene-regulating factors during zebrafish development and discovered that modifications to 'histone H3', one of the ...

Histone post-translational modifications (PTMs) affect many nuclear processes, including gene activation and silencing, by recruitment of protein factors that recognize the PTMs with specialized ...