The amount of genome-scale data on covalent histone modification patterns is rapidly increasing. This Review brings together current knowledge on how modification 'signatures' relate to the ...

DNA methylation and histone modification are important for regulating gene expression and chromatin structure. New evidence suggests there are multiple levels of crosstalk between these marks.

A recent review by Prof. Zhu Bing and Associate Professor Xiong Jun from the Institute of Biophysics of the Chinese Academy ...

Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role ...

In a paper published in Molecular Biomedicine, researchers Xia Peng and Juan Du present a comprehensive review of lysine lactylation (Kla), a post-translational modification discovered in 2019.

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

A recent study has revealed promising targets for treating childhood acute myeloid leukaemia (AML) driven by NUP98 fusion ...

Fruit ripening determines shelf life and consumer appeal, yet the molecular switches that control this process remain ...

Histone modification is an epigenetic mechanism that enables fine-tuning of gene expression. Mutation or dysregulation of proteins associated with histone modification (called “writers,” “erasers,” ...

Posttranslational modifications on histone proteins play a role in regulating chromatin structure and gene expression. Now another so-called histone mark can be added to the list: lysine benzoylation.

Modification of histone tails, by acetylation, methylation or phosphorylation, affects the local chromatin structure and the transcriptional regulation of adjacent genes.Pericentric heterochromatin ...