a phenomenon called `capping', whose outcome is the formation of the immune `synapse', the machinery required for T-cell signaling 9. At present, methods for the detection of antigen-specific T ...

Immune cells called regulatory T cells have long been known for their role in countering inflammation. In the setting of ...

When naive T cells encounter antigen-presenting cells (APCs), membrane and cytoplasmic molecules rearrange at the T cell–APC contact area to form the immune synapse. Finetti et al. now reveal an ...

The immune system is highly trained to detect and eliminate ... 7) Nef also disrupts the proper formation of immunological synapses, the points of communication between T cells and antigen-presenting ...

we have been able to completely redefine synapse formation in the cerebellum," says Yuzaki. The experts confirmed that the ...

This CD2-CD58 interaction is crucial for immune cell activation ... at distances from the synapse center (5, 10, 15 minutes post synaptic formation). (d) Dot plots show MFI of CD61, CD103, and ...

Investigators examined how molecular dynamics at the immune synapse -- where CAR T cells bind to cancer cells -- affect anticancer activity. A study published in Science Advances shares new ...

Investigators from Baylor College of Medicine, Texas Children’s Cancer Center and the Center for Cell and Gene Therapy at Baylor, Houston Methodist Hospital and Texas Children’s Hospital examined how ...

we demonstrate that the acidic pH typically found in solid tumours hinders the efficacy of immune therapies by impeding perforin pore formation within the immunological synapse. A nanometre-scale ...

Effective immune responses against infectious agents and cancer ... and granzyme proteins in intracellular compartments called lytic granules. During synapse formation, these granules coalesce around ...