News

Some two dozen biotech developers of PROTACs, molecular glues and other types of protein-degrading drugs have sprung up over ...
Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. ...
EpiTACs are an example of an extracellular protein degradation therapeutic. These are tissue-specific bispecific antibodies in which one arm binds a target and the other arm binds a degrader receptor.
To unravel this ubiquitin code and understand protein degradation better, Leo Kiss and Brenda Schulman in collaboration with Leo James, head of the research group “Host-Pathogen Biology”, at the MRC ...
Cancer therapies sometimes involve drugs that mediate the breakdown of specific intracellular proteins that participate in cancer formation and proliferation. Proteolysis-targeting chimeras or ...
Targeted protein degradation (TPD) is a promising therapeutic strategy that repurposes machinery within the cell to target faulty proteins for destruction. One such technology, lysosome-targeting ...
The protein complex "Mon1/Ccz1" determines which intracellular vesicles ... 2021 — Researchers have used advanced electron microscopes to delve deeper into the process of protein degradation.
Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in ... PARK7 evades degradation and is instead ...
Decreased protein degradation in cerebellum leads to motor dysfunction. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2020 / 09 / 200923124624.htm ...
03/24/2025 19:21 Cracking the Code of Protein Degradation Dr. Christiane Menzfeld Öffentlichkeitsarbeit Max-Planck-Institut für Biochemie. Ubiquitin marks proteins for degradation, whereby ...