Some two dozen biotech developers of PROTACs, molecular glues and other types of protein-degrading drugs have sprung up over ...

Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. ...

EpiTACs are an example of an extracellular protein degradation therapeutic. These are tissue-specific bispecific antibodies in which one arm binds a target and the other arm binds a degrader receptor.

Cancer therapies sometimes involve drugs that mediate the breakdown of specific intracellular proteins that participate in cancer formation and proliferation. Proteolysis-targeting chimeras or ...

To unravel this ubiquitin code and understand protein degradation better, Leo Kiss and Brenda Schulman in collaboration with Leo James, head of the research group “Host-Pathogen Biology”, at the MRC ...

Contrary to long-standing assumptions, human egg cells stay pristine for decades not by ramping up waste disposal, but by ...

Targeted protein degradation (TPD) is a promising therapeutic strategy that repurposes machinery within the cell to target faulty proteins for destruction. One such technology, lysosome-targeting ...

Many proteins are capable of spontaneously rearranging themselves within cells to form molecular condensates—membraneless ...

Decreased protein degradation in cerebellum leads to motor dysfunction. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2020 / 09 / 200923124624.htm ...

03/24/2025 19:21 Cracking the Code of Protein Degradation Dr. Christiane Menzfeld Öffentlichkeitsarbeit Max-Planck-Institut für Biochemie. Ubiquitin marks proteins for degradation, whereby ...