In this century, Michaelis was a strong proponent, discussing proposed effects of hydration and of pore charge on "capillary ... separate types of ion channels Na, K and leak (L), as well as ...

if the membrane is perfectly selective for potassium ions. You also learned that the slope of the line should have a value of 58 mV for a 10-fold concentration difference at room temperature (rising ...

The opening of just a single ion channel alters the electrical charge on both sides of the membrane. The resulting charge differential then causes adjacent voltage-sensitive channels to open in ...