In most cases of B-ALL with MLL rearrangements (MLLr B-ALL), this gene fuses with another one named AF4, producing a new fusion protein (MLL-AF4) with unexpected activities. A complex series of events ...

Cite this: Recent Advances in the Biology and Management of Primary Acute Myeloid Leukemia with Rearrangements of the MLL Gene - Medscape - May 03, 2000. Strout, MP, Caligiuri, MA, Bloomfield CD.

Mixed lineage leukemia (MLL)-fusion proteins can induce acute myeloid leukemias (AMLs) from either hematopoietic stem cells (HSCs) or granulocyte–macrophage progenitors (GMPs), but it remains ...

Daunorubicine was purchased from Pfizer (Berlin, Germany), BEZ-235, AC220, AZD-6244 and MK-2206 from Selleck Chemicals (Houston, TX, USA), rapamycin from LC Laboratories (Woburn, MA, USA) and ...