Nature Reviews Neurology - Axonal loss linked to MS disability. This new evidence builds on previous research indicating a primary role for axonal pathology in motor deterioration in animals.

We need to identify other factors which -- over and above axonal loss ... Axonal loss in the multiple sclerosis spinal cord revisited. Brain Pathology, 2017; DOI: 10.1111/bpa.12516; ...

When patients are diagnosed with MS and have their first neurological symptoms, axonal loss has already occurred. 6 Because brain atrophy, specifically gray matter atrophy, creates permanent ...

In recent years, the central roles of neuronal and axonal damage, as well as axon–glial and axon–myelin interactions, in the pathogenesis and progression of multiple sclerosis (MS) have become ...

Multiple sclerosis affects more than 2 million people worldwide ... Evangelou N, Ebers GC, Esiri MM. The contribution of demyelination to axonal loss in multiple sclerosis. Brain 2006;129:1507 ...

Imaging studies at the NIH Clinical Center showed that chronic active lesions with a paramagnetic rim exerted ongoing tissue ...

Multiple sclerosis (MS) is an autoimmune disorder that results in incurable disabilities. Now, groundbreaking research conducted by Leipzig University and the Max Planck Institute has posed a new ...

Multiple sclerosis (MS) is a ... leading to irreversible axonal degeneration and formation of sclerotic plaques. 2,28 Although an element of axonal loss is likely present at the earliest ...

Pediatric-onset multiple sclerosis (POMS) is associated with higher likelihood of cognitive impairment and faster decline in information-processing efficiency, in adulthood, than adult-onset ...

While axonal degeneration appears to be a major culprit in diseases like multiple sclerosis, it also paradoxically plays an important role in properly wiring the nervous systems of developing embryos.

In order to survive and power the human brain for its millions of functions, neurons in the cerebral cortex need a steady supply of food. This food comes in the form of regular amounts of proteins and ...

For patients with acute optic neuritis, measuring early optic nerve lesion length may predict neuro-axonal loss and serve as a biomarker for chronic visual impairment in the future. CME.