Chronic, irreversible motor disability in patients with multiple sclerosis (MS) correlates with axonal pathology rather than demyelination, according to new research. During the early stages of MS ...

When patients are diagnosed with MS and have their first neurological symptoms, axonal loss has already occurred. 6 Because brain atrophy, specifically gray matter atrophy, creates permanent ...

Compared to patients with adult-onset MS, those with pediatric onset had a more rapid decline in information-processing efficiency and a higher likelihood of cognitive impairment.

Lead researcher Klaus Schmierer said: "The lack of association between axonal loss and spinal cord cross sectional area significantly changes our understanding of chronic disability in MS.

Imaging studies at the NIH Clinical Center showed that chronic active lesions with a paramagnetic rim exerted ongoing tissue ...

In recent years, the central roles of neuronal and axonal damage, as well as axon–glial and axon–myelin interactions, in the pathogenesis and progression of multiple sclerosis (MS) have become ...

Multiple sclerosis affects more than 2 million people worldwide and is currently incurable. A number of interventions to modify the course of multiple sclerosis have been developed that offer new i ...

For patients with acute optic neuritis, measuring early optic nerve lesion length may predict neuro-axonal loss and serve as a biomarker for chronic visual impairment in the future.

Multiple sclerosis (MS) is an autoimmune disorder that results in incurable disabilities. Now, groundbreaking research conducted by Leipzig University and the Max Planck Institute has posed a new ...

N-acetylaspartate/creatine ratio is significantly lower in the brains of MS patients with increased fatigue, indicating more axonal damage and poorer nerve functioning.

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While axonal degeneration appears to be a major culprit in diseases like multiple sclerosis, it also paradoxically plays an important role in properly wiring the nervous systems of developing embryos.