On this map, the distribution of sickle-cell anemia haplotypes among nations with high prevalence of the disease are shown. Five distinct beta-globin haplotypes (indicated by colors) are found in ...

Sickle Cell disease is an autosomal recessive disorder that causes anemia, joint pain, a swollen spleen, and frequent, severe infections. It illustrates balanced polymorphism because carriers are ...

Researchers found that the sickle cell gene is especially prevalent in areas of Africa hard-hit by malaria. In some regions, as much as 40 percent of the population carries at least one HbS gene.