Amazingly, the molecular breakthroughs in autophagy ... to involve a directed targeting-and-sequestration mechanism. During nonspecific autophagy (see figure part a), sequestration begins with ...

Understanding the molecular mechanisms that initiate autophagy is expected to enhance our knowledge of autophagy-related ...

On a molecular level ... 5d) may serve either of two purposes, in teleological terms. First, autophagy may constitute a mechanism through which the cell destined to die initiates its catabolism ...

Analysis of the molecular mechanism of autophagy in vertebrates is progressing. In the “MIZUSHIMA Intracellular Degradation” ERATO project, a novel autophagy factor that does not exist in yeast was ...

Weak molecular interactions essential for autophagy to begin In order for the degradation of cellular components through autophagy to occur, they must first be recognised as waste. This is done by ...

The paper is published in the journal Molecular Neurodegeneration ... toxic proteins around neurons, the exact mechanism ...

This process, known as autophagy, is like a self-cleaning mechanism for cells, ... Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no ...

Using advanced molecular biology and genetic tools ... future studies should focus on understanding the precise mechanisms of autophagy regulation and its therapeutic application in diverse ...

Abstract Autophagy is a crucial quality control mechanism that degrades damaged cellular components through lysosomal fusion with autophagosomes ...

We hypothesize that some of these autophagy related proteins are crucial for the maintenance of progenitor stem cells in endometrium and thus, we are interested in evaluating the underlying molecular ...

A recent study has uncovered the molecular mechanisms behind osteocyte death in melanoma bone metastasis, revealing that ferroptosis—an iron-dependent form of cell death—plays a central role in the ...