However, these classical models of receptor/G protein coupling may be oversimplified ... between the alpha2c-adrenergic receptor and m3-muscarinic receptor suggested the possible ...

However, despite being the target for 30-40% of all approved drugs 1, these proteins were structurally ... “We had been working in the muscarinic receptor space for almost 20 years,” says ...

Sosei Heptares has taken another of its partnered G protein-coupled receptor (GPCR ... an oral, selective muscarinic M4 receptor agonist, which is the most advanced candidate in a $2.6 billion ...