Calcium handling and excitation-contraction (EC) coupling are critical processes in cardiac myocytes, the muscle cells of the heart. These processes ensure that the heart contracts effectively and ...

Researchers discovered that ICC in the LES activate calcium-activated chloride channels (ANO1), which help maintain the membrane potential of smooth muscle cells, facilitating their contraction.

Calcium channel blockers are a group of medications that act to inhibit either central or peripheral calcium channels. This results in decreased calcium influx and smooth muscle relaxation.

Calcium ions in the muscles attach to proteins called myosin and troponin C. This mechanism alters the shape of these proteins, producing a muscle contraction. When magnesium is present ...

When the calcium channels are broken down, the nerve endings release less acetylcholine. This neurotransmitter acts as a ...

The DHP receptor gene is almost identical to those that encode voltage-gated calcium channels. (You may know that dihydropyridines are widely used antihypertensive drugs that reduce blood pressure by ...