In two studies of nickel allergy in the general population, 0.8% to 0.9% of men were patch test positive whereas 8.0% and 9.0% of women were patch test positive (980 and 1,159 subjects, respectively).

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While more males were allergic to nickel in the late group (2001-2004) as compared to the early group (1992-1995), this difference did not quite achieve statistical significance (p = .067).