IN 1955 Rucknagel et al. 1 described a new abnormal hemoglobin in a Negro family in North Carolina. This hemoglobin, designated "I", migrated more rapidly than normal hemoglobin on filter-paper ...

However, the role of hemoglobin in the understanding of genetic disease has been equally powerful. Over 300 abnormal hemoglobins ... than those of hemoglobin from normal erythrocytes (6. ...

Usually, both genes make a normal hemoglobin protein. When someone inherits two mutant copies of the hemoglobin gene, the abnormal form of the hemoglobin protein causes the red blood cells to lose ...

This is like coding new instructions into the cell. The old instructions for the abnormal hemoglobin S (HbS) are still there, but now the cell can make normal HbA (hemoglobin A) and HbS. The vector ...