A planarian's guide to growing a new head
Cut off any part of this worm's body and it will regrow. This is the spectacular yet mysterious regenerative ability of ...
Nature12y
Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency
to identify a novel Notch gene expression signature that is also found in human T-ALL and is regulated independently of Myc. Cross-species microarray comparisons between zebrafish and mammalian ...
Medscape15d
CADASIL: The Most Common Hereditary Subcortical Vascular Dementia
No writing assistance was utilized in the production of this manuscript. CADASIL is caused by mutations in the NOTCH3 gene (in 19p13.1-13.2) encoding a 280 kDa transmembrane receptor. Virtually ...
The Scientist1y
A Molecular Switch for Bone Loss
Based on these findings, the team examined whether the Notch signaling pathway controls SSPC differentiation, making these cells more likely to become adipocytes with aging. To do so, they used ...
Nature18y
CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to γ-secretase inhibitors
Cleaved intracellular NOTCH (ICN) translocates to the nucleus ... Two PAC clones RP11-370H5 and CTD-3242B16, which span the NOTCH1 gene were obtained from Invitrogen. DNA was labeled by nick ...
Exploring Molecular Switches Application In Modern Therapeutics Download Report
Kuick Research Report Highlights Ongoing Developments In Molecular Switches Application Therapeutic Targets & Drug Delivery ...
Medscape1mon
CADASIL: The Most Common Hereditary Subcortical Vascular Dementia
It is caused by the defective NOTCH3 gene, which encodes a transmembrane receptor; over 170 different mutations are known. The main clinical features are migraine with aura (often atypical or ...