Redesign of the potent painkiller's core prevents breathing suppression and reduces addiction-related behaviours in mice ...

In addition, the metabolites of new psychoactive substances (NPS) have been found to be active, so studying the metabolites and then subsequently studying the potency of the metabolites provides a ...

The unique properties of the atom-thick sheet of carbon, known as graphene, enabled a new penny-sized, multiplexed bio-sensor that’s the first to detect opioid byproducts in wastewater, a team of ...

Since esterase enzymes in the blood rapidly convert heroin to morphine and 6-acetylmorphine through sequential deacetylation, scientists have, until now, identified the metabolites as better targets.

“There are no FDA-approved drugs containing 7-OH, and it is illegal to market any drugs containing 7-OH,” the FDA said.

Due to their small molecular size, opioids can cross the blood-brain barrier (BBB) to cause both the euphoria that makes such drugs so addictive and the adverse effects including the respiratory ...

Kratom is a Southeast Asian tree with a long history of use in traditional medicine. In the region, the plant's leaves are widely consumed for pain relief, treatment of opioid addiction and other ...

Drug use reporting laws should be modernized to protect pregnant people and new mothers being treated for opioid addiction.

We explore how the opioid crisis is affecting grandparent caregivers with a panel of experts.Want to support 1A? Give to your local public radio station and subscribe to this podcast.

FDA approves first non-opioid pain medicine in more than 20 years The drug, Journavx (suzetrigine), inhibits an ion channel in peripheral nerves.

Five times stronger than morphine, [9] hydromorphone also has renally cleared metabolites; however, owing to its higher potency, a much smaller dose can be used for an equianalgesic effect.

But only about a third of adults with opioid use disorder received any type of treatment for substance use, and only about 1 in 5 received medication to treat opioid use disorder, according to the ...