and its downstream mediator protein kinase B (PKB). In addition, SYK mediates differentiation through the adaptor protein SH2-domain-containing leukocyte protein of 65 kDa (SLP65), which induces ...

PKB/AKT, protein kinase B; S6K, ribosomal protein S6 kinase.) However, the discovery of the way in which 'primed' substrates dock with GSK3 might have opened up a new opportunity to develop ...

Jiyong Liang; Judit Zubovitz; Teresa Petrocelli; Rouslan Kotchetkov; Michael K. Connor; Kathy Han; Jin-Hwa Lee; Sandra Ciarallo; Charles Catzavelos; Richard Beniston ...

Terremoto Biosciences Inc. has synthesized new 3H-imidazo[4,5-b]pyridine compounds acting as RAC-α serine/threonine-protein kinase (AKT1; PKB-α) inhibitors reported to be useful for the treatment of ...