An artist's representation of a free-energy landscape and two possible paths a protein might follow (left) to fold correctly and a third path (right) that leads to a misfolded state.

Here we use this method to determine properties of the free-energy surface for folding that have not been obtained from ensemble experiments.

DeepMind AI handles protein folding, which humbled previous software Google's AI specialists tackle biology's toughest computational problem.

Cold denaturation under native conditions The variable position and curvature of the Gibbs free energy of each state in a protein's conformational manifold determine the probability of that state ...

SARS-CoV-2 entry is dependent upon interactions between its spike protein and the host ACE-2 receptor, which is determined by the Gibbs energy of binding.

Biophysicists in Germany have published results of single-molecule experiments bringing a higher-resolution tool to the study of protein folding. They report taking hold of a single, zipper-like ...

According to Ferguson, the single-molecule free energy surface encodes all of the thermodynamics and pathways of folding, dictating protein structure and dynamics.