An artist's representation of a free-energy landscape and two possible paths a protein might follow (left) to fold correctly and a third path (right) that leads to a misfolded state.

Nature - Probing the free-energy surface for protein folding with single-molecule fluorescence spectroscopy Skip to main content Thank you for visiting nature.com.

DeepMind AI handles protein folding, which humbled previous software Google's AI specialists tackle biology's toughest computational problem. John Timmer – Nov 30, 2020 5:10 pm | 75 ...

The variable position and curvature of the Gibbs free energy of each state in a protein's conformational manifold determine ... Mayne, L. & Englander, S.W. Protein folding intermediates: native ...

The Gibbs energy of binding was calculated using the dissociation equilibrium constant, which was then used to calculate the rate of binding of the spike protein to the ACE-2 receptor for each of ...

Full distance resolved folding energy landscape of one single protein molecule. Proceedings of the National Academy of Sciences , 2010; (in press) Cite This Page : ...

According to Ferguson, the single-molecule free energy surface encodes all of the thermodynamics and pathways of folding, dictating protein structure and dynamics.