Chemical probing is a valuable tool for inferring RNA functional secondary structures and tertiary RNA interactions. The gold standards of chemical probing are comparative sequence analysis, ...

RNAs have diverse roles in the cell, and being able to determine their complex secondary and tertiary structures is a key to understanding these roles. Although computational approaches for ...

RNA molecules perform essential cellular functions including gene regulation, protein synthesis, and genome defense. These diverse biochemical activities frequently depend on RNA secondary and ...

Since RNA is charged, metal ions such as Mg2+ are needed to stabilise many secondary and tertiary structures. RNA tertiary structures are determined using chemical probing and modification ...

Their performance has been benchmarked by comparing structure predictions to reference secondary structures. Generally, algorithms are compared against each other and one is selected as best without ...

Scientists have encountered many cases of RNA forming a double-stranded (a.k.a. secondary) structure that plays an important role in the functioning of RNA molecules. These structures are involved ...

In my head, RNA often resembles tangled headphones. It starts as a string, but subsequently tangles into a loop-de-loop—like twisting a rubber band. That twisty structure then twists again with ...

The genome of the SARS virus is a single strand of RNA that folds into regular repeating patterns to form secondary structures such as helices. These then fold and bend in three dimensions to form ...

New results from ultrafast spectroscopy and in-depth theoretical calculations demonstrate that the complex folded structure of tRNA is stabilized by magnesium ions in direct contact with phosphate ...