There are two important regulators of collagen production: transforming growth factor (TGF)-b and activator protein (AP)-1. TGF-b is a cytokine that promotes collagen production (MassaguE9, 1998).

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M10 likewise reduced collagen production induced in normal cells by administration of TGF-β1 without affecting baseline collagen levels.

The following day cells were stimulated with TGF-β1 dose response prepared in assay media then cultured for 72 hours. Cells were fixed and immunostained for collagen I (total and extracellular ...

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Similarly, "they ameliorated TGF-beta1-induced fibrosis ex vivo in human skin, with reductions in collagen content of approximately 40%," he told BioWorld Science. The mnAbs were then demonstrated to ...

Background: Elevated levels of TGF-b expression are associated with poor prognosis in breast cancer and TGF-b is an immunosuppressive cytokine that is thought to play an essential role in tumor immune ...

When TGF was blocked with an antibody, the mice's bones withstood "higher maximum load and ultimate strength" and showed "improved whole bone and tissue strength", suggesting "resistance to ...