Polypeptides, including bradykinin, kallikrein, chromogranin A, glucagon, motilin, neurokinin B, neurokinin K ... led to the hypothesis that fibrosis is driven by TGF-β1. Serum levels of CTGF ...

Fibrogenesis. Increased matrix production is the most direct way that stellate cell activation generates hepatic fibrosis. The most potent stimulus to collagen I production is TGF-beta ...

Both STP705 and STP707 are made of two siRNA oligonucleotides that hit transforming growth factor beta 1 (TGF-β1) and cyclooxygenase 2 (COX-2) mRNA, gatekeeper targets for oncology and fibrosis.

In many diseases, there are high concentrations of TGF-Beta that result in a spectrum of negative downstream effects including inflammation, fibrosis, neoinnervation, hyperexcitability of nerves ...