Varenicline might be more effective than bupropion. A new drug for smoking cessation, varenicline (Chantix), was approved by the FDA in May 2006. As a partial agonist of a nicotinic acetylcholine ...

[5] Figure 1 illustrates varenicline's mechanism of action at the α4ß2 receptor site as a partial agonist. 1 Department of Pharmacy, Cleveland Clinic, Cleveland, OH, and Ambulatory Care ...