Neurofibrillary tangles mark Alzheimer’s disease and a plethora of primary tauopathies. How best to study them in the lab? Most mouse tauopathy models overexpress the human tau protein and are highly ...

Creating models for primary tauopathies sounds simple enough. Select a human tau gene variant that causes disease, stick it where the endogenous mouse gene sits in its genome, then wait a few months ...

Now that doctors are prescribing anti-amyloid therapies for Alzheimer’s disease, scientists have begun to focus their energy on the other pathological hallmark of AD, neurofibrillary tangles. While ...

From April 24-25, the Tau Global Conference, a.k.a. Tau2025, drew 600 people to a hotel in Hyde Park, London, with 500 more following the science online. Attendance well surpassed Tau2020, the first, ...

What are physicians learning from their early experiences prescribing amyloid immunotherapy? In the May 12 JAMA Neurology, Joy Snider and Suzanne Schindler and colleagues at Washington University, St.

In a milestone for Alzheimer’s disease diagnosis and care, the U.S. Food and Drug Administration on May 16 cleared for marketing the first AD blood test. Fujirebio’s Lumipulse G p-tau217/Aβ42 ...

Perhaps our most defining characteristic as a species, the six-layered human cortex, hosts billions of neural connections that bestow Homo sapiens with higher-order thinking. But how does this ...

As biomarker testing becomes more common in Alzheimer’s research, scientists face the tricky question of whether to disclose results. In studies of hypothetical scenarios, including a recent survey ...

Clusterin, we’re sorry—we misjudged you. Long cast as Aβ’s villainous sidekick (Jan 2014 news; Apr 2023 news), the chaperone now looks more like a friendly superhero. Provided, that is, our genes let ...

Cells, are you experiencing stress? Quick, SUMOylate your TDP-43 before it’s too late! Three independent papers appearing in rapid succession deliver the same message: Chain the small ubiquitin-like ...

Converging evidence suggests that hearing loss during midlife increases a person’s odds of getting dementia. Now, research from Johns Hopkins’ Bloomberg School of Public Health, Baltimore, suggests ...

Tau pulls the plug on the neural activity that forms memories, according to researchers led by Marc Aurel Busche at the U.K. Dementia Research Institute at University College London. On April 23 in ...