Gene expression is linked to RNA transcription, which cannot happen without RNA polymerase. However, this is where the similarities between prokaryote and eukaryote expression end. Central to the ...

Once bound, RNA polymerase unwinds a short stretch of DNA, forming a transcription bubble, and begins synthesizing the mRNA transcript using one of the DNA strands (the template strand).

One way to get RNA polymerase going again involves a molecule known as UvrD helicase. Through a series of in vitro and in vivo experiments, Nudler’s team showed how this molecule pulls the ...

coli ?70 in the nucleation and maintenance of the single stranded DNA bubble in open RNA polymerase-promoter complexes. J. Biol. Chem. 276, 31891-31896. Auble, D.T. and deHaseth, P.L. 2002.

DExH/D box proteins are required for the major transactions of RNA, including ... SNF2 and vaccinia virus transcription termination factor NPH-I. NPH-I acts on the RNA polymerase ternary complex ...

RNA molecules perform essential cellular functions including gene regulation, protein synthesis, and genome defense. These diverse biochemical activities frequently depend on RNA secondary and ...