Glucose levels influence physiology and adaptation rates under replication stress, yet core adaptive mutations remain ...

Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

This month's cover highlights the article EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer by Dana Krauß, Maria Sibilia and colleagues. The tumor-intrinsic role of ...

PHOSPHATE STARVATION RESPONSE 1 (PHR1) is a master transcription factor involved in the Pi starvation in A. thaliana.Under Pi starvation conditions, PHR1 binds to the PHR1‐binding site (P1BS) element ...

In this study, using C. elegans and human cell lines, we characterized the physiological effects of thiol reductive stress. Because thiol antioxidants result in the increased expression of rips‐1 ...

Despite clinical benefits of tyrosine kinase inhibitors (TKIs) in cancer, most tumors can reactivate proliferation under TKI therapy. Here we present transcriptional profiling of HER2+ breast cancer ...

miPEP31, encoded by the primary transcript of miR‐31, is a cell‐penetrating peptide which promotes Treg differentiation. Synthesized miPEP31 enhances the induction of peripheral Tregs and suppresses ...

To overcome this challenge, cells use sterol products of the mevalonate pathway to negatively regulate its activity at two critical nodes. The first of these nodes is the sterol regulatory ...

Arabidopsis genome encodes approximately 60 putative MAPKKKs, 10 MAPKKs, and 20 MAPKs (MAPK‐Group, 2002).MAPK cascades have been shown to regulate diverse aspects of plant biology, including plant ...

DDX5 is the most abundant RNA helicase and is aberrantly expressed in most malignant tumors, where it participates in transcriptional regulation, differentiation, metastasis, and regulation of various ...

Macrophages not only clean the wound early for repair, but are also critically involved in all subsequent phases of proliferation and regeneration (Mirza et al, 2009; Shook et al, 2016).They ...