Miley Cyrus teamed up with Brittany Howard to cover "Nothing Compares 2 U," the hit made famous by Sinéad O'Connor, on Sunday's SNL50 special.

Two years after she made her Saturday Night Live debut as host, Aubrey Plaza was back on the show for the SNL50 anniversary special, introducing one of the musical performances. This marked Plaza’s first public appearance since her husband,

One standout moment was Miley Cyrus and Brittany Howard’s duet of “Nothing Compares 2 U,” a song written by Prince and made famous by Sinéad O’Connor. The former Disney Channel star later thanked Brittany in an Instagram post,

SNL50: The Anniversary Special” offered something for all fans: Those who come for the music (Lil Wayne and The Roots; Miley Cyrus and Brittany Howard; Paul McCartney), for viewers who love the recurring sketches/characters (Mike Myers’ Linda Richman;

Miley Cyrus and Brittany Howard appeared to honor Sinéad O’Connor during “SNL50: The Anniversary Special” on Sunday night. The duo, who also performed during the “Saturday Night Live” concert special two nights prior,

Aubrey Plaza, who once interned for SNL, returned to studio 8H for SNL 50 to introduce Miley Cyrus and Brittany Howard pay tribute to Sinéad O’Connor.

Wayne was among the star-studded cast, including Miley Cyrus, Paul McCartney, and Brittany Howard. Wayne's medley lasted for about 5 minutes and the singer addressed his audience with a simple "Thank you" and marked the 50th Anniversary.

Miley Cyrus and Brittany Howard performed Sinéad O'Connor's "Nothing Compares 2 U" more than three decades after the Irish singer's "SNL" controversy.

Live officially turned 50 on October 11, 2025, and to mark the celebrations it hosted the Saturday Night Live 50: The Homecoming concert at the Radio City Music Hall in New York City.

Miley Cyrus and Brittany Howard paid tribute to Sinead O'Connor with a cover of "Nothing Compares 2 U" at SNL50 anniversary special.

Miley Cyrus and Brittany Howard covered "Crazy Little Thing Called Love" in a nod to Queen's final public performance in North American prior to Freddie Mercury's passing.

O'Connor also has her own complicated history with the sketch comedy program, following her infamous tearing of the Pope's picture on a 1992 episode.